abstract：:Some orthopoxviruses are considered to be potential biological weapons. After the smallpox eradication campaign ended, routine vaccination was stopped around the world. Consequently, a significant portion of the population is now completely unprotected from infection by variola virus and related orthopoxviruses. Some ...

journal_title：British journal of biomedical science

authors： Sánchez-Seco MP,Hernández L,Eiros JM,Negredo A,Fedele G,Tenorio A

更新日期：2006-01-01 00:00:00

abstract：:Maternal diabetes is associated with an increased rate of congenital fetal anomaly. In the present study, diabetes was induced by streptozotocin in female rats one week prior to conception and the embryos were examined during organogenesis. Experimental diabetes is associated with over-production of free radicals and ...

journal_title：British journal of biomedical science

authors： El-Bassiouni EA,Helmy MH,Abou Rawash N,El-Zoghby SM,Kamel MA,Abou Rayah AN

更新日期：2005-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a major determinant of heart damage. Scientific evidence suggests the influence of genetic factors, but these have yet to be completely clarified. This study investigates a possible relationship between LVH and two chemokine receptor (CCR) gene polymorphisms: CCR5delta32 and CCR26...

journal_title：British journal of biomedical science

authors： Mettimano M,Specchia ML,La Torre G,Bruno A,Ricciardi G,Romano-Spica V,Savi L

更新日期：2005-01-01 00:00:00

abstract：:Trichomonas vaginalis (TV) is one of the most successful protozoan pathogens and one of the most common sexually transmitted organism in females, yet it is also one of the most poorly investigated. By producing a wide array of glycosidases and cysteine proteinase enzymes, the organism can easily adapt to the environme...

journal_title：British journal of biomedical science

authors： Rughooputh S,Greenwell P

更新日期：2005-01-01 00:00:00

abstract：:In this study, flagellin is purified biochemically from eight urease-positive thermophilic camplylobacters (UPTC) isolated from river water, sea water and mussels, and purified also from two isolates of Campylobacter jejuni and C. coli and fractionated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS...

journal_title：British journal of biomedical science

authors： Sekizuka T,Seki K,Hayakawa T,Moore JE,Murayama O,Matsuda M

更新日期：2004-01-01 00:00:00

abstract：:Vaccinia virus is a member of the orthopoxvirus group, to which also belongs variola virus, one of the most hazardous pathogens known to man. To establish a model system to detect orthopoxviruses, a vaccinia oligonucleotide microarray is designed, produced and tested. Vaccinia virus is used to test the prepared microa...

journal_title：British journal of biomedical science

authors： Wenli M,Yan W,Hongmin W,Wenling Z

更新日期：2004-01-01 00:00:00

abstract：:This study looks at the possible role of some non-traditional risk factors for premature coronary artery disease (CAD) and assesses the presence of relationship between these factors and the traditional cardiovascular risk factors. The study subjects (n=45) are divided into three groups comprising 15 premature CAD pat...

journal_title：British journal of biomedical science

authors： Barghash NA,Elewa SM,Hamdi EA,Barghash AA,El Dine R

更新日期：2004-01-01 00:00:00

abstract：:A strategy for identifying toxoplasma immunity in pregnancy must provide good evidence of immunity but not falsely reassure; that for immunocompromised patients should identify immunity and also the risk of reactivated toxoplasmosis. Using sera from both of these patient groups, the performance of an in-house IgG EIA ...

journal_title：British journal of biomedical science

authors： Ashburn D,Evans R,Chatterton JM,Joss AW,Ho-Yen DO

更新日期：2003-01-01 00:00:00

abstract：:HLA-B27 is a serological specificity which encompasses an increasing number of subtypes that show varied racial/ethnic prevalence in the world. Here, data from 5129 Indians (4500 population and caste; 629 tribal) is compiled from the literature. In addition, HLA-B27 subtyping of 58 positive individuals from Maharastra...

journal_title：British journal of biomedical science

authors： Shankarkumar U

更新日期：2003-01-01 00:00:00

abstract：:The offspring of coronary heart disease (CHD) patients are at particularly high risk for developing CHD. Endothelial dysfunction is present in the majority of CHD and atherosclerosis patients. Fish oil, rich in n-3 fatty acids has been shown to augment endothelium-dependent vasodilatation in human peripheral and coron...

journal_title：British journal of biomedical science

authors： Yosefy C,Khalamizer V,Viskoper JR,Iaina A,Manevich I,London D,Jafari J,Magen E,Wollman Y,Reisin L

更新日期：2003-01-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Increased sympathetic activity is associated with an increased left ventricular (LV) mass. However, the influence of TH gene polymorphisms on LV structure and function has yet to be investigated. Here, we analyse the association of Val...

journal_title：British journal of biomedical science

authors： Linhart A,Jindra A,Golán L,Jáchymová M,Sedlácek K,Peleska J,Umnerová V,Bultas J,Horký K,Aschermann M

更新日期：2002-01-01 00:00:00

abstract：:Lactic acid bacteria are the dominant bacteria of the vaginal tract in healthy women. Lactobacillus species form a barrier population that protects from pathogen colonisation by mechanisms that include adhesion to epithelial surfaces, self-aggregation and co-aggregation. In this study, factors involved in the self-agg...

journal_title：British journal of biomedical science

authors： Ocaña VS,Nader-Macías ME

更新日期：2002-01-01 00:00:00

abstract：:B-cell chronic lymphocytic leukaemia (B-CLL) is a clinically heterogeneous disease characterised by the accumulation of a clonal population of B lymphocytes. This accumulation is considered to result from the prolonged survival of B-CLL cells arrested in the G0 stage of the cell cycle. However, when cultured in vitro,...

journal_title：British journal of biomedical science

authors： Jewell AP

更新日期：2002-01-01 00:00:00

abstract：:Nitric oxide (NO), a labile free radical synthesised from L-arginine by the action of nitric oxide synthase (NOS), is said to be implicated in uraemic complications, such as infection and a tendency to bleed. In this study of NO production by peripheral blood cells, an increased level is seen in platelets from uraemic...

journal_title：British journal of biomedical science

authors： Fayed HM,Kamel MA,Sultan MM,Mowafy MN,Helmy MH,El-Zoghby SM

更新日期：2002-01-01 00:00:00

abstract：:Nucleic acid amplification (NAA) methods for the diagnosis of genital Chlamydia trachomatis infection perform well but are technically demanding. Strand displacement amplification (SDA) assay is a new NAA method that offers technical simplicity but its comparative diagnostic performance is unknown. Here, we compare th...

journal_title：British journal of biomedical science

authors： McCartney RA,Walker J,Scoular A

更新日期：2001-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are major causative agents in the pathogenesis of cervical cancer, and more than twenty types are associated with its development. With the introduction of liquid-based preparation systems, it is envisaged that large-scale HPV testing will be established in the near future. Preliminary st...

journal_title：British journal of biomedical science

authors： Brennan MM,Lambkin HA,Sheehan CD,Ryan DD,O'Connor TC,Kealy WF

更新日期：2001-01-01 00:00:00

abstract：:Nitric oxide (NO) and malondialdehyde (MDA) play a significant role in DNA damage, sister-chromatid exchanges (SCEs) and carcinogenesis. Here, we determine plasma NO and MDA to evaluate their role in carcinogenesis and their effect on the frequency of SCEs in 45 female breast cancer patients and in 35 age- and sex-mat...

journal_title：British journal of biomedical science

authors： Ray GN,Shahid M,Husain SA

更新日期：2001-01-01 00:00:00

abstract：:The scarcity of viable tissue samples for leukaemia research is widely recognised and currently restrictive. Archival bone-marrow smears present a valuable resource that can be exploited easily for mutational analysis. Here, a modified technique to extract DNA is described, and used subsequently for mutation/polymorph...

journal_title：British journal of biomedical science

authors： Court EL,Davidson K,Smith MA,Inman L,Marriott SA,Smith JG,Pallister CJ

更新日期：2001-01-01 00:00:00

abstract：:Multimedia computer-aided learning (CAL) is an area that has become increasingly prevalent in biomedical science. Here we describe the advances that have taken place in the computing industry that have led to this trend. We also outline areas within the subject of biomedical science that can most benefit from using mu...

journal_title：British journal of biomedical science

authors： Ryan M,Mulholland CW,Gilmore WS

更新日期：2000-01-01 00:00:00

abstract：:Design of a spreadsheet to evaluate the performance of internal quality control sera used for the validation of immunoassays in virology is described. Developed using Microsoft Excel 97, it can set target limits and analyse control data by application of Westgard quality control rules. It also provides a permanent rec...

journal_title：British journal of biomedical science

authors： Wright JD

更新日期：2000-01-01 00:00:00

abstract：:This study investigates the effect of ergonomic intervention on working posture and musculoskeletal symptoms in female biomedical scientists. The Nordic musculoskeletal questionnaire (NMQ), body discomfort chart (BDC) and rapid upper-limb assessment (RULA) are the tools for assessment. The study was conducted in three...

journal_title：British journal of biomedical science

authors： Kilroy N,Dockrell S

更新日期：2000-01-01 00:00:00

abstract：:In recent years, there has been heightened interest in the B vitamin folic acid, initially through its role in reducing neural tube defects, such as spina bifida, and, more recently, through its relationship with homocysteine and consequently the beneficial role it would seem to play in occlusive vascular disease. In ...

journal_title：British journal of biomedical science

authors： Lucock M,Daskalakis I

更新日期：2000-01-01 00:00:00

abstract：:When infected with Leishmania donovani, patients develop specific antibodies that constitute the basis of serodiagnosis. Using immunoblot analysis, we examined the antibody response to antigens of L. donovani in 35 kala-azar (KA) patients and 67 controls. Sera from KA patients recognised numerous antigens with molecul...

journal_title：British journal of biomedical science

authors： Salotra P,Raina A,Negi NS

更新日期：1999-01-01 00:00:00

abstract：:Diarrhoeal diseases remain a major cause of mortality and morbidity in developing countries. However, due to lack of funds, supply problems and some inexperience, some laboratories have difficulty identifying a causative agent in stool samples. In the year following the opening of the Shaukat Khanum Memorial Cancer Ho...

journal_title：British journal of biomedical science

authors： Bhatti AR,Danish F,Wadood A,Mortlock S

更新日期：1999-01-01 00:00:00

abstract：:Leptin is a protein, produced by adipose tissue, which has cytokine and hormonal properties. Serum leptin levels can be considered as a measure of body fat mass, and are involved in regulation of body weight. Previous studies suggest that leptin may have an additional role in reproduction, and there is also evidence f...

journal_title：British journal of biomedical science

authors： Quinton ND,Laird SM,Okon MA,Li TC,Smith RF,Ross RJ,Blakemore AI

更新日期：1999-01-01 00:00:00

abstract：:This study characterised the levels of serum immunoglobulin G (IgG), cerebrospinal fluid IgG (CSF IgG) and IgG index as an aid to the diagnosis and prognosis of acute bacterial meningitis (ABM). A total of 28 patients with proven ABM at admission (age range: one month to 10 years; 17 males, 11 females) (group A) and 1...

journal_title：British journal of biomedical science

authors： Giasuddin AS,Shembesh NM,el-Bargathy SM,Kashbur IM,Rao BN

更新日期：1998-12-01 00:00:00

abstract：:Over a six-month period, 857 faecal samples were submitted to the Department of Microbiology and Immunology at Sultan Qaboos University Hospital in Oman, for routine microbiological examination. All samples were stained using the Gomori trichrome method. Trophozoites of Dientamoeba fragilis were detected in 41 (5.1%) ...

journal_title：British journal of biomedical science

authors： Windsor JJ,Rafay AM,Shenoy AK,Johnson EH

更新日期：1998-09-01 00:00:00

abstract：:The past two decades have seen a huge increase in the study of angiogenesis or neovascularisation. With it has come realisation of the crucial role that angiogenesis plays in the growth and metastatic potential of carcinoma. One area where there has been particular interest is in the measurement of angiogenesis in bre...

journal_title：British journal of biomedical science

authors： Magennis DP

更新日期：1998-09-01 00:00:00

abstract：:The performance of four dedicated carbon monoxide (CO)-oximeters (AVL, Chiron, IL, Radiometer), spectrophotometry with and without dithionite, spectrophotometry by second derivative, and the Whitehead and Worthington precipitation technique for the measurement of carboxyhaemoglobin in blood was compared by a mean of 1...

journal_title：British journal of biomedical science

authors： Barnett K,Wilson JF

更新日期：1998-06-01 00:00:00

abstract：:In response to an outbreak of a plague-like disease in India, the Public Health Laboratory Service (PHLS) in the UK distributed advice on the isolation and identification of Yersinia pestis. Some of the procedures outlined were evaluated using a number of isolates of Y. pestis, complemented with in-house techniques de...

journal_title：British journal of biomedical science

authors： Russell P,Nelson M,Whittington D,Green M,Eley SM,Titball RW

更新日期：1997-12-01 00:00:00

abstract：:The pathogenesis of the lupus anticoagulant (LA) has been the focus of much research over the past decade, and a plethora of laboratory tests have been developed to detect it. This essay reviews the nature of LA and its pathogenesis, and a number of approaches employed in its diagnosis. These range from well establish...

journal_title：British journal of biomedical science

authors： Court EL

更新日期：1997-12-01 00:00:00

abstract：:Immunoassays and bioluminescence assays of bile acids in serum have provided relatively simple and sensitive methods for assessing the concentration of selected sub-groups of bile acids. However, these assays do not provide full data for each of the individual bile acids. The recent development of sensitive techniques...

journal_title：British journal of biomedical science

authors： Azer SA,Klaassen CD,Stacey NH

更新日期：1997-06-01 00:00:00

abstract：:The recognition of unusual, but important, pathogens such as Burkholderia pseudomallei is essential for the rapid implementation of appropriate antimicrobial therapy--delays can be fatal. Melioidosis should be considered as a potential diagnosis for any patient with exposure to areas of endemicity, and thus laboratori...

journal_title：British journal of biomedical science

authors： Walsh AL,Wuthiekanun V

更新日期：1996-12-01 00:00:00

abstract：:Cytokines are known to have a key role in the onset and development of inflammatory joint disease, including rheumatoid arthritis and osteoarthritis. The effects of some cytokines on the cells and tissues involved in inflammation of the joint are well catalogued, but recent discoveries of new cytokines, and interest i...

journal_title：British journal of biomedical science

authors： Moulton PJ

更新日期：1996-12-01 00:00:00

abstract：:A review of some of the outbreaks of disease caused by echoviruses demonstrates their ability to cause significant morbidity and mortality world-wide. There are now 30 recognised echovirus serotypes; several of the original serotypes have been re-classified. More recently, echovirus 22 has been shown to have significa...

journal_title：British journal of biomedical science

authors： Hill WM

更新日期：1996-09-01 00:00:00

abstract：:The epidemics of puerperal fever in the 18th and 19th centuries began soon after the creation of Lying-in hospitals in the mid-18th century. The primary purpose of these hospitals was to provide physicians with training in obstetrics in general and in forceps deliveries in particular. The first reports describing epid...

journal_title：British journal of biomedical science

authors： Bridson EY

更新日期：1996-06-01 00:00:00

abstract：:The ID-Sampler II, an automated liquid handling system, is designed specifically for use with current gel technology. It was found to be reliable, easy to use and fully alarmed, making it a 'walk-away' instrument. Over a three-month period samples for ABO/Rh(D) grouping, antibody screening and compatibility testing we...

journal_title：British journal of biomedical science

authors： Parker PI,Scott Y,McArdle B,Wallis JP

更新日期：1995-12-01 00:00:00

abstract：:A new histochemical reagent has been developed utilising a lectin from a marine alga for the first time. Colloidal gold was coupled to the N-acetyl-alpha-D-galactosamine specific lectin from the green alga Codium fragile ssp. tomentosoides. The lectin--gold conjugate bound to the membranes of blood-group A1 human eryt...

journal_title：British journal of biomedical science

authors： Griffin RL,Rogers DJ,Spencer-Phillips PT,Swain L

更新日期：1995-09-01 00:00:00

abstract：:Transforming growth factor-beta is a 25 kD polypeptide produced by both healthy and neoplastic cells. This cytokine effects the introduction of immune response, but its exact mechanism remains to be elucidated. In this paper the immuno-regulatory role of this cytokine on both the immunocompetent cells and accessory mo...

journal_title：British journal of biomedical science

authors： Sosroseno W,Herminajeng E

更新日期：1995-06-01 00:00:00

abstract：:One hundred gonococcal isolates, representing eight protein IA serovars and 14 protein IB serovars, were stored at -70 degrees C using the Pro-Lab Microbank cryovial storage system. At monthly intervals a bead from each cryovial was removed and cultured on modified New York City medium. The overall recovery rate was 9...

journal_title：British journal of biomedical science

authors： Moyes A,Young H

更新日期：1995-03-01 00:00:00